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Problem Set 3
1.Regulation and feedback
In the following example shown in lecture,assume that the arterial pressure with the renin-‐ngiotensin system is restored to 80 mm Hg. What type of feedback is this an example of?
(positive or negative)Calculate the gain of the feedback mechanism. In the example shown, by
what mechanism does the renin-‐angiotensin system regulate blood pressure?What would happen to the gain of the feedback if this person was taking an inhibitor of the angiotensin-‐converting enzyme to treat their hypertension (high blood pressure)? Why?
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2.Renal filtration and re-absorption A crazy professor injected himself with inulin (NOT insulin)to a plasma concentration of 0.1mg/ml. Over the next 30 minutes, he passed 300 ml of urine –the concentration of inulin in the urine was 1.3 mg/ml.He continued to collect his urine
over a 24 hour period – the total volume was 1.5 liters. The concentration of Na+, K+ and Cl-‐ in the 24-‐hour sample of urine was 100 mEq/L, 60 mEq/L and 150 mEq/L.(You can look up the normal plasma concentrations of these ions)
a) Calculate the percentage of filtered Na+, K+ and Cl-‐ that was reabsorbed by the kidney tubules (show all of your calculations).
b)He then takes the spironolactone pills prescribed by his physician.What effect would this
have on the amounts of Na+ and K+ excreted in his urine in the over the next 24 hours?
C)Further analysis of the urine shows significant amounts of glucose in the urine.
What does this tell you about the glucose concentration in the blood?How does the presence of
glucose in the urine affect the volume of urine produced?
3.The microbiome and obesity (Contributed by Katherine Smith,former GSI)The colon has a vast microbiome that varies between humans.There is work that suggests that some bacterial strains might be causative for leanness or obesity.
How would you go about finding such bacterial strains?How you would test each strain, include
controls and state your expected results. Limit your answer to one half page.
4.Design an organ! (Contributed by Shannon Hateley, former GSI) Design an extra organ for the
human body that adds a new and useful function. Try to integrate it with other systems –look
at the body as a whole.Be creative! It can be funny or serious.Limit your answer to one half page.Drawings are OK.Include some of the following in your design
What nervous systems innervate your organ?(sympathetic,parasympathetic,somatic)
What receptors and transporters are present on your organ?(adrenergic,acetylcholine,glucose
Does your organ communicate directly with any other organs? What channels are present on the
organ?Can it generate action potentials?Does it have pace maker cells?For example:The Dessert Stomach: There’s always room for dessert!The dessert stomach is an extra stomach that is only for dessert.
No matter how much dinner you’ve had, you can still be hungry for desert because the empty dessert stomach is there waiting especially for after-‐dinner treats. Since it is a digestive organ the desert stomach will primarily be stimulated by the parasympathetic nervous system via muscarinic acetylcholine receptors.It could also have leptin receptors, except that when leptin is released to signal to the rest of the body to be full,leptin has a different action on the dessert stomach to accommodate more dessert etc.
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